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Connection Between Low Testosterone Levels and Depression

Published : 02/19/2016 21:10:30
Categories : Hormons , Treatments

The decrease of testosterone, the male sex hormone, which occurs in men after 40 years as part of the process called andropause, has been linked to depression and states of anxiety.

While the mechanisms, according to a study published in the journal of Biological Psychiatry are unknown, there is an area of ​​the hippocampus (part of the brain involved in memory functions and responses to stress) which is mediating the antidepressant effect of testosterone.

In addition to andropause, other conditions characterized by decreased secretion of male hormones are also associated with depression. Such is the case of hypogonadism. On the other hand, the lower concentration of testosterone, explains why women are more likely than men to have the disease until age 65.

A study conducted by Mohamed Kabbaj showed that intravenous administration of testosterone to rats reduced the symptoms of depression thereof. In addition, they detected a molecular marker (MAPK / ERK2), which is involved in the antidepressant effect of testosterone.

In another study conducted by the University of Western Australia and published in Achieves of General Psychiatry, 4000 men over 70 years were analyzed and found that those who had lower testosterone levels were three times more likely to experience depression.

Researchers also concluded that this hormone can affect the level of certain neurotransmitters related to calm and sense of well-being, such as serotonin; which are diminished in the majority of patients with depression.

Despite these findings, it is important to consider other factors that can influence mood and the development of this pathology. According to Professor Stafford Lightman, an endocrinologist at the University of Bristol, depression is triggered as a result of the interaction of various factors. Therefore, it is important to consider low testosterone levels as a risk factor and not as a decisive factor.

The most common symptoms of depression in men with low testosterone levels are:

  • Dysphoric mood or loss of interest or pleasure in daily activities, with sadness, despair or apathy, lack of initiative and irritability.
  • Decreased sexual motivation, loss of energy and fatigue.
  • Feelings of worthlessness, self-reproach or constant feeling of guilt.
  • Decreased ability to concentrate and indecision.
  • Changes in body weight and eating patterns
  • Sleep disorders such as insomnia or hypersomnia.

In some patients, it depends on the personality and stress tolerance traits of insecurity and guilt, the degree of environmental dependency and how to socialize, all of which can act as a catalyst to trigger a pathological sadness.

Usually, the patient is reluctant to be evaluated, for fear of being stigmatized, or think that his self-esteem will be further affected, all leading to a vicious circle and everything gets worse, if it is not properly diagnosed with a blood test.

When depression is mainly caused by decreased testosterone levels, intravenous application of this hormone is a highly effective  treatment and with a very low grade of adverse effects.

To get started with your treatment, just call Dr. Jean Garant on +34 952 770 714, or Email him today to book your consultation.


  1. Testosterone therapy for men. Medline Plus. 
  2. Efectos psicológicos de la andropausia sobre la depresión.  

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